Reyes was involved in a traffic collision in Utrera, the town of his birth located just outside of Seville, in Spain this morning.
According to Spanish TV channel Deportes Cex, the crash, which happened at around 11:40am, is believed to have occurred on a road between Utrera and Seville and two more people were in the car.
Cesc Fabregas has written an emotional tribute in memory of Jose Antonio Reyes
Fabregas and Reyes became close friends while representing Arsenal between 2004 and 2007
He leaves behind three children; daughters Noelia and Triana, son Jose Antonio Jr and wife Noelia Lopez, who he married in June 2017.
It is reported one of of the other people in the car, his 23-year-old cousin, Jonathan Reyes, also died while the third occupant suffered burns.
Fabregas’ translated message reads: ‘My first great friend in the world of professional football, my roommate, who always wanted to sleep with the air conditioning even at -10 degrees.
(L-R) Phillipe Senderos, Manuel Almunia, Reyes and Fabregas celebrate winning the FA Cup
Fabregas and Reyes embrace while representing Spain in 2007
‘A humble guy who always had a smile on his face, great footballer and great person. I could not wake up today in a worse way. I will never forget when you and your family welcomed me at your home in my first Christmas in England when I was alone and was 16 years old.
‘I will never forget our tennis football matches in the gym before and after workouts. Our connection in the field was also special, since it was always easy to find yourself between the lines so you could make the difference.
‘I always say that you have been one of the greatest talents in football and I know that I am not wrong. 2 days ago I was talking about you in an interview, it might be a sign, who knows, to remember you, my great friend.
(L-R) Reyes, Almunia and Fabregas pose for a picture with the Community Shield in 2005
Fabregas described Reyes as ‘a humble guy who always had a smile on his face’
‘I will never forget you, we will never forget you. Always in our hearts. Rest in peace Jose Antonio Reyes. Love you very much. Cesc’.
Reyes was a member of Arsenal’s Invincibles in the 2003/04 season and played with Fabregas at the north London club between 2004 and 2006.
Reyes won the Premier League (2004), FA Cup (2005) and Community Shield (2005) at Arsenal and lifted the Europa League trophy five times with Atletico Madrid and Sevilla.
Reyes and Fabregas prepare their kit in the home dressing room at Arsenal’s Highbury Stadium
Fabregas described the late Reyes as ‘one of the greatest talents in football’
The Spaniard, who won 21 caps, had been playing in the Spanish second-tier since January this year after signing a five-month deal with Extremadura.
All seven second division games due to be played at the club have been postponed and will instead be played on Tuesday.
There will also be a minute’s silence for the player before the Champions League Final in Madrid.