The Gunners are 14th in the table, taking four wins and four losses from their first nine games this season.
While their opponents are four places ahead, sitting just on point ahead of them on 14 points.
Nuno Espirito Santo’s team pose some attacking threats to the north London side, with Adama Traore’s pace on the wing and Raul Jimenez’s eye for goal.
And Wolves have enjoyed the better form between the two teams since their Premier League promotion two years ago, drawing twice at the Emirates Stadium.
But Arteta won the latest encounter in July as Bukayo Saka and Alexandre Lacazette both found the net.
The Spanish manager will have both players to call on for the latest match-up between the two – and could make a tactical decision.
With Traore and Daniel Podence set to run at them, defensive cover and the ability to counter-attack may see Arteta stick with the 4-5-1.
The line would be led by top-scorer Pierre-Emerick Aubameyang, who is looking for his third league goal in 10 games.
With Bernd Leno between the posts, Hector Bellerin and Kieran Tierney would slot into their usual full-back positions as Gabriel Magalhaes and Rob Holding form a centre-back pairing.
David Luiz was forced off the pitch with injury concerns in the Europa League win over Molde, meaning he is unlikely to be available.
Mohamed Elneny is expected to return from his Covid-19 quarantine period, meaning he would slot into a defensive midfield pairing with Granit Xhaka.
Arteta is still without summer signing Thomas Partey, who would slot into this position, with a thigh injury.
Nicolas Pepe’s absence would allow Saka to start, whose injury scare in the 0-0 draw against Leeds was a dead leg.
The Englishman would slot into the left wing, accompanying right-sided Willian, who missed the Molde win with a minor injury but is expected to be available.
Joe Willock returned to form as he made two assists in the Europa League victory on Thursday, which could earn a place behind Aubameyang in the midfield.
His last Premier League appearance at Elland Road came just a day after crashing his Mercedes on the M25.
Expected Arsenal XI vs Wolves – Leno; Bellerin, Holding, Magalhaes, Tierney; Elneny, Xhaka; Willian, Willock, Saka; Aubameyang