WARNING: GRAPHIC CONTENT
The Potters lost 2-1 to the 2016 Premier League champions.
Leicester’s record signing Youri Tielemans got the winning goal after Marc Albrighton’s opener was equalled by Nick Powell.
But the result was overshadowed by Shawcross’ injury after 40 minutes as footage shows.
In a clip from the game, the two sides are level.
The ball is in Stoke’s half, with Leicester on the attack.
And it is played to Albrighton, running on the left wing – but he has Shawcross sprinting to defend.
The Stoke defender wins the race and clears the ball off the goal line.
But he pays a huge price as his left leg appears to bend at the shin.
“No hate, that’s actually horrible to see”
AFTV on Ryan Shawcross
And he is immediately in pain, screaming and calling for the medical team.
This footage was shared on Twitter earlier today, where it has already been viewed more than 90,000 times.
Several viewers were left shocked at the incident.
“F***, that doesn’t look good,” one said.
While another commented: “That looks painful.”
Popular Arsenal fan show AFTV wrote on Twitter: “No hate, that’s actually horrible to see.”
This refers to Shawcross’ horror tackle on Gunners star Aaron Ramsey in February 2010.
Playing at the then-Britannia Stadium, the Welshman suffered a double fracture to the right leg from the Stoke man’s tackle.
There has been tension between Arsenal and Stoke fans since but AFTV’s tweet earned praise.
One user commented: “Big up robbie. You know twitter is too juvenile.”
While another said: “I am gutted and no one did to him it was how he landed his leg.”