The Gunners travel to Brammall Lane to take on Chris Wilder’s newly-promoted Blades in what could be a tricky encounter.
However, Unai Emery will be looking at a near-clean bill of health ahead of their clash with two stars returning.
One of them is Lacazette, who has been missing since their 2-2 draw against Tottenham , and would provide a huge boost to their attack.
The Frenchman has been training for over a week and could be in contention to start upon the return of the Premier League.
And there is also a return to fitness for Emile Smith Rowe, who suffered a concussion against Nottingham Forest at the end of last month.
The 19-year-old had been ruled out for two weeks but has been given the all-clear.
Smith Rowe, who spent a portion of last season on loan to RB Leipzig last season, has not featured in the Premier League yet this campaign.
However, there is bad news for another Arsenal youngster after Reiss Nelson was hit with injury while on international duty.
The 19-year-old withdrew from the England Under-21 side and could miss up to seven matches for the Gunners.
Meanwhile, ex-Prem striker Michael Owen has given his predictions over the upcoming clash in Sheffield.
“Sheffield United have failed to score in their last three games in all competitions but they were, arguably, unlucky not to pick up a point against Liverpool in their last home game,” he told BetVictor.
“Arsenal have only conceded once in their last four games in all competitions, but I would not be surprised if the Gunners had to settle for a point at Bramall Lane on Monday.
“Chris Wilder’s side have not lost by more than one goal in the league so far this campaign and I think they will get a draw against the Gunners.”